Immune Modulation of Pain and Addiction for Comprehensive Therapeutics

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Publications from the IMPACT Lab (lab members underlined)

Totsch, S. K., Quinn, T. L., Strath, L. J., McMeekin, L. J., Cowell, R. M., Gower, B. A. & Sorge, R. E. (in press). The impact of the standard American diet in rats: effects on behavior, physiology and recovery from inflammatory injury. Scandinav J Pain

Totsch, S. K. & Sorge, R. E. (2017). Immune system involvement in specific pain conditions. Mol Pain. Epub Jan 1.

Martin, L. J., Smith, S. B., Khoutorsky, A., Magnussen, C. A., Samoshkin, A., Sorge, R. E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khuong, T. M., Mir, E., Gibson, D. G., Wieskopf, J. S., Sotocinal, S. G., Austin, J. S., Meloto, C. B., Gitt, J. H., Gkogkas, C.,Sonenberg, N., Greenspan, J., Fillingim, R. B., Ohrbach, R., Slade, G. D., Knott, C., Dubner, R., Nackley, A. G., Ribeiro-da-Silva, A., Neely, G. G., Maixner, W., Zaykin, D. Z., Mogil, J. S., & Diatchenko, L. (2017). Involvement of epiregulin and epidermal growth factor receptor in pain. Journal of Clinical Investigations. Epub Aug 7.

​Taylor, J. C., Dewberry, L. S., Totsch, S. K., Yessick, L. R.
, DeBerry, J. J., Watts, S. A. & Sorge, R. E. (2017). A novel zebrafish-based model of nociception. Physiology & Behavior, 174:  83-88.

Merlin, J. S., Westfall, A. O., Heath, S. L., Goodin, B. R., Stewart, J. C., Sorge, R. E., Younger J. W. (2017). IL-1β levels are associated with chronic multisite pain in people living with HIV. J Acquir Immune Def Syndr, 75: e99-e103.

Sorge, R. E. & Totsch, S. K. (2017). Sex differences in pain. Journal of Neuroscience Research, 95: 1271-1281.

Totsch, S. K., Waite, M. E., Tomkovich, A., Quinn, T. L., Gower, B. A. & Sorge, R. E. (2016) Total Western Diet Alters Mechanical and Thermal Sensitivity and Prolongs Hypersensitivity Following Complete Freund's Adjuvant in Mice. J Pain, 17: 119-125.

Khoutorsky, A., Bonin, R. P., Sorge, R. E., Gkokas, C., Jafarnejad, M., Alain, T., Perez-Sanchez, J., Martin, L. J., De Koninck, Y., Mogil, J. S. & Sonenberg, N. (2015). Translational control of nociception via 4E-binding protein 1.eLife.

Sorge, R. E, Mapplebeck, J. C, Rosen, S., Beggs, S., Taves, S., Alexander, J. K., Martin, L. J., Austin, J. S., Sotocinal, S., Chen, D., Yang, M., Shi, X. Q., Huang, H., Pillon, N. J., Bilan, P. J., Tu, Y., Klip, A., Ji, R. R., Zhang, J., Salter, M. W., Mogil, J. S. (2015). Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci, 18: 1081-3.

Kim, J. Y., Tillu, D. V., Quinn, T. L., Mejia, G. L., Shy, A., Asiedu, M. N. K., Murad, E., Totsch, S. K., Sorge, R. E., Mantyh, P. W., Dussor, G. & Price, T. J. (2015). Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. J Neuroscience, 35: 6307-17.

Waite, M. E., Tomkovich, A., Quinn, T. L., Schumann, A. P., Dewberry, L. S., Totsch, S. K. & Sorge, R. E. (2015). Efficacy of common analgesics for spontaneous postsurgical pain in rats. JAALAS, 54: 420-5.

Totsch, S. K., Waite, M. E., & Sorge, R. E. (2015). Dietary influence on pain via the immune system. In T. J. Price & G. O. Dussor (Eds). Molecular Biology of Pain, Progress in Molecular and Translational Science. Elsevier. 131: 435-69.

Tillu, D. V., Hassler, S. N., Burgos-Vega, C. C., Quinn, T. L., Sorge, R. E., Dussor, G., Boitano, S., Vagner, J. & Price T. J. (2015). Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state. Pain, epub Feb 12.

Cahill, L. S., Laliberte, C. L., Liu, X. J., Bishop, J., Nieman, B. J., Mogil, J. S., Sorge, R. E., Jones, C. D., Salter, M. W. & Henkelman R. M. (2014). Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse. Mol Pain, 10: 60.

Si, Y., Cui, X., Kim, S., Wians, R., Sorge, R. E., Oh, S., Al-Sharabati, M., Lu, L., Claussen, G., Anderson, T., Yu, S., Morgan, D., Kazamel, M., & King, P. H. (2014). Smads as biomarkers in amyotrophic lateral sclerosis. Annals Clin Transl Neurol, 10: 778-87.

​Sorge, R. E., Martin, L. J., Isbester, K. A., Sotocinal, S. G., Rosen, S., Tuttle, A. H., Weiskopf, J. S., Acland, E. L., Dokova, A., Kadoura, B., Leger, P., Mapplebeck, J. C. S., McPhail, M., Delaney, A., Wigerblad, G., Schumann, A. P., Quinn, T., Frasnelli, J., Svensson, C.I., Sternberg, W. F. & Mogil, J. S. (2014). Olfactory exposure to males, including human males, produces stress and stress-induced analgesia in rodents. Nature Methods, 11: 629-632.